Relations between the US and the EU are expected to improve during the presidency of Joe Biden, but it is not yet clear whether the disagreements Europe had with Biden’s predecessor, Donald Trump, were about methods or substance. Washington and Brussels can work together on issues like climate change and can probably find synergies in international organizations, but their understanding of security challenges remains different. The most likely area in which they can cooperate effectively is the creation of a coordinated Western approach to the problem of COVID-19.