Israel is making a serious political-diplomatic effort to strengthen relations with African countries, particularly several key northern and sub-Saharan states. The parties are seeking enhanced cooperation in trade, energy, food security, climate security, water security, agriculture, cyber security, and defense. These efforts come at a time when Israel’s global diplomatic network is expanding significantly. The political realignments taking place in the Middle East could open up opportunities for trilateral or multilateral partnerships involving Israel, its African partners, and other like-minded countries from the region and beyond.