US Vice President J.D. Vance returned from Pakistan without achieving an Iran war settlement. For Israel, this failure is concerning not just because it signifies continuing nuclear danger from Iran, but because it portends further regional destabilization and nuclear proliferation. For Israel, nuclear threats are not just about Iran. Even a favorable end to the current war could produce another dangerous enemy or configuration of enemies. Over time, this adversary (e.g., Egypt, Turkey, Saudi Arabia) could create a new risk of nuclear war, even if it were to remain non-nuclear. Jihadi terrorist groups could also act as force-multiplying surrogates of an “Iran replacement enemy”. To prepare for such threats, Jerusalem will need to engage in comprehensive theorizing, not the visceral seat-of-the-pants policies and intra-crisis hyperbole favored by US President Donald J. Trump. To enhance the credibility of its nuclear deterrent, Israel should consider ending its policy of nuclear ambiguity.